Senior Principal Scientist, Psychiatry

That’s why we’re seeking a Senior Principal Scientist, Psychiatry accountable for planning and overseeing the scientific strategy and delivery of psychiatry-focused clinical trial services across a portfolio of studies. This role is responsible for ensuring the scientific integrity, quality, and consistency of endpoint data collection, including rater training, scale administration, and central monitoring methodologies. The role provides scientific leadership across a portfolio of studies, supporting study design implementation and the development of services for psychiatric indications (e.g., MDD, schizophrenia, bipolar disorder). Responsibilities include oversight of rater training programs, central monitoring frameworks, and data quality strategies to support reliable and valid clinical trial outcomes.

Key Responsibilities

• Oversee the scientific delivery of psychiatry clinical trial services across a portfolio of studies, including rater training and central monitoring.
• Contribute to definition and implementation of study-specific delivery plans for endpoint quality, including integration of central monitoring and review workflows.
• Provide direction to internal study teams on feasibility, scale selection, administration standards, and timing of deliverables.
• Serve as the primary scientific point of contact for assigned studies, ensuring clarity and consistency in internal and sponsor communications.
• Contribute to design and implementation of rater training programs (e.g., MADRS, HAM-D, HAM-A, YMRS), including certification, calibration, and remediation pathways.
• Monitor central monitoring outputs, including identification of data quality signals, rater drift, and protocol deviations, and guide appropriate follow-up actions.
• Support the resolution of scientific and data quality escalations arising from central monitoring and study review activities.
• Develop central monitoring resources to systematize feedback.
• Collaborate with Project Management to ensure efficient and profitable delivery of services, including resource allocation and workflow optimization.
• Contribute to the development and standardization of SOPs, training materials, and operational guidelines for psychiatry trials.
• Support staff development within scientific and rater training teams, including mentoring and performance feedback.
• Contribute to the development and refinement of psychiatry-focused products and services, including rater training programs, central monitoring methodologies, and scale-specific guidance.
• Support innovation in endpoint quality assurance and approaches for detecting data quality issues.
• Contribute to the design and interpretation of metrics related to rater performance, endpoint reliability, and data quality.
• Analyze patterns in clinical trial data to identify risks such as placebo response inflation, rater drift, and scoring inconsistencies.
• Provide scientific consultation on study design, scale selection, administration strategy, and risk mitigation.
• Support business development through scientific input in proposals
• Drive scientific dissemination through publications, conference presentations, and internal knowledge-sharing initiatives.
• Contribute to advancing best practices in psychiatric endpoint assessment and central monitoring.

Requirements

• Tertiary qualifications or post graduate degree in the area of psychology, psychiatry, neuroscience, or related field
• Evidence of scientific track record in publications, conference presentations, patents or gra